[div class=attrib]From Discover:[end-div]

“There are no shortcuts in evolution,” famed Supreme Court justice Louis Brandeis once said. He might have reconsidered those words if he could have foreseen the coming revolution in biotechnology, including the ability to alter genes and manipulate stem cells. These breakthroughs could bring on an age of directed reproduction and evolution in which humans will bypass the incremental process of natural selection and set off on a high-speed genetic course of their own. Here are some of the latest and greatest advances.

Embryos From the Palm of Your Hand
In as little as five years, scientists may be able to create sperm and egg cells from any cell in the body, enabling infertile couples, gay couples, or sterile people to reproduce. The technique could also enable one person to provide both sperm and egg for an offspring—an act of “ultimate incest,” according to a report from the Hinxton Group, an international consortium of scientists and bioethicists whose members include such heavyweights as Ruth Faden, director of the Johns Hopkins Berman Institute of Bioethics, and Peter J. Donovan, a professor of biochemistry at the University of California at Irvine.

The Hinxton Group’s prediction comes in the wake of recent news that scientists at the University of Wisconsin and Kyoto University in Japan have transformed adult human skin cells into pluripotent stem cells, the powerhouse cells that can self-replicate (perhaps indefinitely) and develop into almost any kind of cell in the body. In evolutionary terms, the ability to change one type of cell into others—including a sperm or egg cell, or even an embryo—means that humans can now wrest control of reproduction away from nature, notes Robert Lanza, a scientist at Advanced Cell Technology in Massachusetts. “With this breakthrough we now have a working technology whereby anyone can pass on their genes to a child by using just a few skin cells,” he says.

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