The stresses of modern day living are taking a toll on your mind and body. And, more so if you happen to live in an concrete jungle. The results are even more pronounced for those of us living in large urban centers. That’s the finding of some fascinating new brain research out of Germany. Their simple answer to a lower-stress life: move to the countryside.

From The Guardian:

You are lying down with your head in a noisy and tightfitting fMRI brain scanner, which is unnerving in itself. You agreed to take part in this experiment, and at first the psychologists in charge seemed nice.

They set you some rather confusing maths problems to solve against the clock, and you are doing your best, but they aren’t happy. “Can you please concentrate a little better?” they keep saying into your headphones. Or, “You are among the worst performing individuals to have been studied in this laboratory.” Helpful things like that. It is a relief when time runs out.

Few people would enjoy this experience, and indeed the volunteers who underwent it were monitored to make sure they had a stressful time. Their minor suffering, however, provided data for what became a major study, and a global news story. The researchers, led by Dr Andreas Meyer-Lindenberg of the Central Institute of Mental Health in Mannheim, Germany, were trying to find out more about how the brains of different people handle stress. They discovered that city dwellers’ brains, compared with people who live in the countryside, seem not to handle it so well.

To be specific, while Meyer-Lindenberg and his accomplices were stressing out their subjects, they were looking at two brain regions: the amygdalas and the perigenual anterior cingulate cortex (pACC). The amygdalas are known to be involved in assessing threats and generating fear, while the pACC in turn helps to regulate the amygdalas. In stressed citydwellers, the amygdalas appeared more active on the scanner; in people who lived in small towns, less so; in people who lived in the countryside, least of all.

And something even more intriguing was happening in the pACC. Here the important relationship was not with where the the subjects lived at the time, but where they grew up. Again, those with rural childhoods showed the least active pACCs, those with urban ones the most. In the urban group moreover, there seemed not to be the same smooth connection between the behaviour of the two brain regions that was observed in the others. An erratic link between the pACC and the amygdalas is often seen in those with schizophrenia too. And schizophrenic people are much more likely to live in cities.

When the results were published in Nature, in 2011, media all over the world hailed the study as proof that cities send us mad. Of course it proved no such thing – but it did suggest it. Even allowing for all the usual caveats about the limitations of fMRI imaging, the small size of the study group and the huge holes that still remained in our understanding, the results offered a tempting glimpse at the kind of urban warping of our minds that some people, at least, have linked to city life since the days of Sodom and Gomorrah.

The year before the Meyer-Lindenberg study was published, the existence of that link had been established still more firmly by a group of Dutch researchers led by Dr Jaap Peen. In their meta-analysis (essentially a pooling together of many other pieces of research) they found that living in a city roughly doubles the risk of schizophrenia – around the same level of danger that is added by smoking a lot of cannabis as a teenager.

At the same time urban living was found to raise the risk of anxiety disorders and mood disorders by 21% and 39% respectively. Interestingly, however, a person’s risk of addiction disorders seemed not to be affected by where they live. At one time it was considered that those at risk of mental illness were just more likely to move to cities, but other research has now more or less ruled that out.

So why is it that the larger the settlement you live in, the more likely you are to become mentally ill? Another German researcher and clinician, Dr Mazda Adli, is a keen advocate of one theory, which implicates that most paradoxical urban mixture: loneliness in crowds. “Obviously our brains are not perfectly shaped for living in urban environments,” Adli says. “In my view, if social density and social isolation come at the same time and hit high-risk individuals … then city-stress related mental illness can be the consequence.”

Read the entire story here.