Tag Archives: Google

Sergey Brin’s Search for a Parkinson’s Cure

[div class=attrib]From Wired:[end-div]

Several evenings a week, after a day’s work at Google headquarters in Mountain View, California, Sergey Brin drives up the road to a local pool. There, he changes into swim trunks, steps out on a 3-meter springboard, looks at the water below, and dives.

Brin is competent at all four types of springboard diving—forward, back, reverse, and inward. Recently, he’s been working on his twists, which have been something of a struggle. But overall, he’s not bad; in 2006 he competed in the master’s division world championships. (He’s quick to point out he placed sixth out of six in his event.)

The diving is the sort of challenge that Brin, who has also dabbled in yoga, gymnastics, and acrobatics, is drawn to: equal parts physical and mental exertion. “The dive itself is brief but intense,” he says. “You push off really hard and then have to twist right away. It does get your heart rate going.”

There’s another benefit as well: With every dive, Brin gains a little bit of leverage—leverage against a risk, looming somewhere out there, that someday he may develop the neurodegenerative disorder Parkinson’s disease. Buried deep within each cell in Brin’s body—in a gene called LRRK2, which sits on the 12th chromosome—is a genetic mutation that has been associated with higher rates of Parkinson’s.

Not everyone with Parkinson’s has an LRRK2 mutation; nor will everyone with the mutation get the disease. But it does increase the chance that Parkinson’s will emerge sometime in the carrier’s life to between 30 and 75 percent. (By comparison, the risk for an average American is about 1 percent.) Brin himself splits the difference and figures his DNA gives him about 50-50 odds.

That’s where exercise comes in. Parkinson’s is a poorly understood disease, but research has associated a handful of behaviors with lower rates of disease, starting with exercise. One study found that young men who work out have a 60 percent lower risk. Coffee, likewise, has been linked to a reduced risk. For a time, Brin drank a cup or two a day, but he can’t stand the taste of the stuff, so he switched to green tea. (“Most researchers think it’s the caffeine, though they don’t know for sure,” he says.) Cigarette smokers also seem to have a lower chance of developing Parkinson’s, but Brin has not opted to take up the habit. With every pool workout and every cup of tea, he hopes to diminish his odds, to adjust his algorithm by counteracting his DNA with environmental factors.

“This is all off the cuff,” he says, “but let’s say that based on diet, exercise, and so forth, I can get my risk down by half, to about 25 percent.” The steady progress of neuroscience, Brin figures, will cut his risk by around another half—bringing his overall chance of getting Parkinson’s to about 13 percent. It’s all guesswork, mind you, but the way he delivers the numbers and explains his rationale, he is utterly convincing.

Brin, of course, is no ordinary 36-year-old. As half of the duo that founded Google, he’s worth about $15 billion. That bounty provides additional leverage: Since learning that he carries a LRRK2 mutation, Brin has contributed some $50 million to Parkinson’s research, enough, he figures, to “really move the needle.” In light of the uptick in research into drug treatments and possible cures, Brin adjusts his overall risk again, down to “somewhere under 10 percent.” That’s still 10 times the average, but it goes a long way to counterbalancing his genetic predisposition.

It sounds so pragmatic, so obvious, that you can almost miss a striking fact: Many philanthropists have funded research into diseases they themselves have been diagnosed with. But Brin is likely the first who, based on a genetic test, began funding scientific research in the hope of escaping a disease in the first place.

[div class=attrib]More from theSource here.[end-div]

The society of the query and the Googlization of our lives

[div class=attrib]From Eurozine:[end-div]

“There is only one way to turn signals into information, through interpretation”, wrote the computer critic Joseph Weizenbaum. As Google’s hegemony over online content increases, argues Geert Lovink, we should stop searching and start questioning.

A spectre haunts the world’s intellectual elites: information overload. Ordinary people have hijacked strategic resources and are clogging up once carefully policed media channels. Before the Internet, the mandarin classes rested on the idea that they could separate “idle talk” from “knowledge”. With the rise of Internet search engines it is no longer possible to distinguish between patrician insights and plebeian gossip. The distinction between high and low, and their co-mingling on occasions of carnival, belong to a bygone era and should no longer concern us. Nowadays an altogether new phenomenon is causing alarm: search engines rank according to popularity, not truth. Search is the way we now live. With the dramatic increase of accessed information, we have become hooked on retrieval tools. We look for telephone numbers, addresses, opening times, a person’s name, flight details, best deals and in a frantic mood declare the ever growing pile of grey matter “data trash”. Soon we will search and only get lost. Old hierarchies of communication have not only imploded, communication itself has assumed the status of cerebral assault. Not only has popular noise risen to unbearable levels, we can no longer stand yet another request from colleagues and even a benign greeting from friends and family has acquired the status of a chore with the expectation of reply. The educated class deplores that fact that chatter has entered the hitherto protected domain of science and philosophy, when instead they should be worrying about who is going to control the increasingly centralized computing grid.

What today’s administrators of noble simplicity and quiet grandeur cannot express, we should say for them: there is a growing discontent with Google and the way the Internet organizes information retrieval. The scientific establishment has lost control over one of its key research projects – the design and ownership of computer networks, now used by billions of people. How did so many people end up being that dependent on a single search engine? Why are we repeating the Microsoft saga once again? It seems boring to complain about a monopoly in the making when average Internet users have such a multitude of tools at their disposal to distribute power. One possible way to overcome this predicament would be to positively redefine Heidegger’s Gerede. Instead of a culture of complaint that dreams of an undisturbed offline life and radical measures to filter out the noise, it is time to openly confront the trivial forms of Dasein today found in blogs, text messages and computer games. Intellectuals should no longer portray Internet users as secondary amateurs, cut off from a primary and primordial relationship with the world. There is a greater issue at stake and it requires venturing into the politics of informatic life. It is time to address the emergence of a new type of corporation that is rapidly transcending the Internet: Google.

The World Wide Web, which should have realized the infinite library Borges described in his short story The Library of Babel (1941), is seen by many of its critics as nothing but a variation of Orwell’s Big Brother (1948). The ruler, in this case, has turned from an evil monster into a collection of cool youngsters whose corporate responsibility slogan is “Don’t be evil”. Guided by a much older and experienced generation of IT gurus (Eric Schmidt), Internet pioneers (Vint Cerf) and economists (Hal Varian), Google has expanded so fast, and in such a wide variety of fields, that there is virtually no critic, academic or business journalist who has been able to keep up with the scope and speed with which Google developed in recent years. New applications and services pile up like unwanted Christmas presents. Just add Google’s free email service Gmail, the video sharing platform YouTube, the social networking site Orkut, GoogleMaps and GoogleEarth, its main revenue service AdWords with the Pay-Per-Click advertisements, office applications such as Calendar, Talks and Docs. Google not only competes with Microsoft and Yahoo, but also with entertainment firms, public libraries (through its massive book scanning program) and even telecom firms. Believe it or not, the Google Phone is coming soon. I recently heard a less geeky family member saying that she had heard that Google was much better and easier to use than the Internet. It sounded cute, but she was right. Not only has Google become the better Internet, it is taking over software tasks from your own computer so that you can access these data from any terminal or handheld device. Apple’s MacBook Air is a further indication of the migration of data to privately controlled storage bunkers. Security and privacy of information are rapidly becoming the new economy and technology of control. And the majority of users, and indeed companies, are happily abandoning the power to self-govern their informational resources.

[div class=attrib]More from theSource here.[end-div]